Medications/Drug Interactions Checker

Drug Interactions Checker

Check drug-drug interactions for multiple medications simultaneously

Enter Medications
Warfarin 5mg Aspirin 81mg Amiodarone 200mg Digoxin 0.125mg Lisinopril 10mg Potassium Cl 20mEq
6 drugs entered. 6 interaction pairs found. Review results on the right.
Interaction Results (6 found)
Warfarin + AspirinMajor
Concurrent use significantly increases the risk of bleeding. Aspirin inhibits platelet aggregation and can displace warfarin from protein binding sites, leading to elevated INR.
Action: Avoid combination unless benefits outweigh risks. If concurrent use is necessary, monitor INR closely and watch for signs of bleeding. Consider PPI for GI protection.
Warfarin + AmiodaroneMajor
Amiodarone inhibits CYP2C9, the primary enzyme responsible for warfarin metabolism. This significantly increases warfarin levels and bleeding risk. INR can increase dramatically within days.
Action: Reduce warfarin dose by 30-50% when initiating amiodarone. Monitor INR weekly for 6-8 weeks, then monthly. Alert prescriber immediately.
Digoxin + AmiodaroneModerate
Amiodarone decreases renal clearance of digoxin and inhibits P-glycoprotein, increasing digoxin plasma concentrations by 70-100%. Risk of digoxin toxicity.
Action: Reduce digoxin dose by 50% when initiating amiodarone. Monitor digoxin levels and signs of toxicity (bradycardia, visual disturbances, nausea).
Lisinopril + Potassium ChlorideModerate
ACE inhibitors like lisinopril increase potassium retention. Concurrent potassium supplementation may cause hyperkalemia, particularly in patients with renal impairment.
Action: Monitor serum potassium levels regularly. Adjust potassium supplementation based on levels. Avoid if K+ >5.0 mEq/L.
Lisinopril + AspirinMinor
High-dose aspirin (≥325mg) may reduce the antihypertensive and cardioprotective effects of ACE inhibitors. Low-dose aspirin (81mg) generally has minimal clinical significance.
Action: Monitor blood pressure. Low-dose aspirin (81mg) is generally acceptable with ACE inhibitors for cardiovascular protection.
Aspirin + AmiodaroneMinor
Both agents have antiplatelet/anticoagulant properties. Combined use may slightly increase bleeding risk beyond individual risks.
Action: Monitor for unusual bruising or bleeding. Patient counseling recommended.